Socioeconomic and psychosocial predictors of interleukin-6 in the MIDUS national sample.

نویسندگان

  • Jennifer A Morozink
  • Elliot M Friedman
  • Christopher L Coe
  • Carol D Ryff
چکیده

OBJECTIVE To investigate whether psychosocial factors (i.e., depression, anxiety, and well-being) moderated educational gradients in interleukin-6 (IL-6) levels using data from the Survey of Midlife Development in the U.S. (MIDUS). The influences of educational attainment and psychosocial factors on IL-6 in middle aged and older adults were also examined. DESIGN Telephone interviews and mail surveys were utilized to collect educational attainment and psychosocial information from respondents (N = 1028). Respondents also participated in an overnight clinic visit, during which health information and a fasting blood sample were obtained. MAIN OUTCOME MEASURES Serum levels of IL-6. RESULTS Greater educational attainment predicted lower levels of IL-6 independent of age and gender, although this effect was attenuated after taking health behaviors, body mass index, waist-to-hip ratio, and chronic illnesses into account. Psychological well-being interacted with education to predict IL-6, such that for those with less education, higher well-being was associated with lower levels of IL-6. CONCLUSION The findings indicate a strong association between education and inflammation, which can be further moderated by psychosocial factors. The health benefits associated with psychological well-being were particularly evident for individuals with low educational attainment.

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عنوان ژورنال:
  • Health psychology : official journal of the Division of Health Psychology, American Psychological Association

دوره 29 6  شماره 

صفحات  -

تاریخ انتشار 2010